|
KMID : 0361120110250020071
|
|
Korean Journal of Transplantation
2011 Volume.25 No. 2 p.71 ~ p.75
|
|
|
Pathogenesis of Transplant Glomerulopathy
|
|
Lim Beom-Jin
Jeong Hyeon-Joo
|
|
|
Abstract
|
|
|
Transplant glomerulopathy is a late complication of renal transplantation. The characteristic morphology of transplant
glomerulopathy includes thickening of glomerular capillary loops with double contour, and duplication of glomerular
basement membrane on electron microscopy. Clinical and experimental evidences support the role of antibody-mediated
immune mechanism in the development of transplant glomerulopathy. Antibody-induced endothelial cell injury is the key
pathogenesis of transplant glomerulopathy. The evolution of transplant glomerulopathy in the context of immunologic injury
is briefly reviewed.
|
|
|
KEYWORD
|
|
|
Kidney glomerulus, Kidney transplantation, Graft rejection, Humoral immunity
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|